KinMet

Past KinMet Meeting Programs

Washington 2001

• Overview of Apolipoprotein B Kinetics. Julian Marsh, New England Medical Center
• Multi-compartmental Models of HDL Metabolism. Hugh Barrett, University of Western Australia
• The Physiome Sciences vision: Integrated database and modeling tools for accelerating preclinical investigation. Thomas Colatsky, Physiome Sciences Inc, Princeton
• Assembly and secretion of apoB from cultured hepatocytes: Insights derived from multicompartmental modeling. Nica Borradaile, Robarts Research Institute, London, Ontario
• LpA-I kinetics in non-human primates and transgenic mice. John Parks, Wake Forest University, Winston-Salem
• From Chaos to Specific Leads: Using the Integrated CellTek(TM) Simulation and Database Systems for Biological Pathway Prediction. John Armstrong, New World Science and Technology Inc, Silver Spring, MD
• ApoB secretion in homozygous familial hypercholesterolemia. John Millar, University of Pennsylvania
• Preliminary analysis of small Lp A-I turnover in human subjects. Perry Colvin, VA Hospital, Baltimore, MD
• ProcessDB: Development of a Database Tool Supporting Large Scale Modeling in Individual Laboratories. Robert D. Phair, BioInformatics Services, Rockville, MD
• HDL Subspecies: Effects of Defective Reverse Cholesterol Transport, Inhibition of Cholesterol Synthesis, and Dietary Saturated Fat and Cholesterol Restriction in Humans. Bela Asztalos, Tufts University
• KBTool: A simple, coherent, extensible strategy for managing biological information. Stephen Shaw, National Cancer Institute, NIH
• ApoB Metabolism in Homozygous Tangier Disease: Effects of Defective Reverse Cholesterol Transport. Ernst Schaefer, Tufts University
• Interrelationships between Human ApoB and ApoA-I Metabolism. Francine Welty, Harvard University
• Future Directions for KinMet. Robert Phair, Bioinformatics Services, Rockville, MD

Salt Lake 2002

• Levy Lecture - Apolipoprotein B Metabolism:  From Mice to Men” Henry Ginsberg, Columbia University College of Physicians and Surgeons
• Berman/Zech Lecture - A history of modeling: Where are we today and where are we going? David Foster, University of Washington
• An introduction to population kinetic analysis. Paolo Vicini, University of Washington
• ApoCIII and apoE kinetics in VLDL of normolipidemic and hyperlipidemic humans. Jeffrey Cohn, Heart Research Institute, Sydney
• The kinetics of the HDL apolipoproteins A-I, A-IV, and E within triglyceride-rich lipoproteins. Ernie Schaefer, Tufts University
• Advances in Modeling Atherosclerotic Plaque Microvasculature in vivo. Andrew Hooker, University of Washington
• Inhibition of both the apical sodium-bile acid  cotransporter and HMG-CoA reductase: Impact on the plasma kinetics of apolipoprotein B. Dawn Telford, University of Western Ontario
• Differential effects of atorvastatin and fenofibrate of HDL apoAI metabolism. Hugh Barrett, University of Western Australia
• HDL Metabolism in HDL Deficiency. Benoit Lamarche, Laval University

Washington DC 2003

• Levy Award Lecture 1 - Application of Stable Isotope Methodology to Lipoprotein Metabolism. Julian Marsh, Tufts University
• Levy Award Lecture 2 - ApoB Metabolism in Combined Hyperlipidemia: Application of Stable Isotope Methodology. Dennis Cryer, Bristol-Myers Squibb
• Berman/Zech Award Lecture - Lipoprotein Cholesterol Ester Metabolism in Humans. Charles Schwartz, Virginia Commonwealth University
• Intracellular trafficking of the ABCB11 Bile Acid Transporter. Irwin Arias, Tufts University
• Commentary on cholesterol ester metabolism in rabbits. Hugh Barrett, University of Western Australia
• Lipid Homeostasis: Gene Regulation through Protein Trafficking. Peter Espenshade, Johns Hopkins School of Medicine
• ApoB Metabolism of Different VLDL Subspecies. Frank Sacks, Harvard University
• HDL, CETP and HDL Subspecies Metabolism. Ernst Schaefer, Tufts University
• Movement and homeostasis of cell cholesterol. Yvonne Lange, Rush-Presbyterian-St Luke's Medical Center
• Visualizing phosphoinositide dynamics in live cells. Tamas Balla, NICHD, NIH
• Effects of Fenofibrate on Lipoprotein Metabolism. Hugh Barrett, University of Western Australia
• Intracellular Trafficking of the ABCA1 Transporter. Ed Neufeld, NHLBI, NIH
• Effects of statins on apoB metabolism. Muriel Caslake, Royal Infirmary, Glasgow
• Apolipoprotein B48 kinetics using a stable isotope in heterozygotes for familial hypercholesterolemia carrying the same null LDL receptor mutation 1:45 Patrick Couture - Laval University -
• Use of the multiple stable isotope approach to quantitate fatty acid sources in postprandial apoB-lipoproteins. Elizabeth Parks, University of Minnesota
• Comments on writing rate laws for nonlinear models of cellular systems: Is it time to abandon the classical concept of concentration? Bob Phair, Integrative BioInformatics Inc

San Fransisco 2004

• Levy Award Lecture - Advances in HDL Metabolism. Bryan Brewer, National Institutes of Health
• A theoretical consideration in an integrated pool model for VLDL apoB and TG kinetics and delipidation. Sekhar Ramakrishnan, Columbia University
• ApoB Kinetics in hepatic lipase deficient patients treated with fibrates. Benoît Lamarche, Laval University
• Role of CETP in HDL metabolism and Atherosclerosis. Ernie Schaefer, Tufts University
• HDL metabolism: a model of LpAI:AII kinetics. Hugh Barrett, University of Western Australia
• Lipoprotein lipase bound to apoB lipoproteins in humans: role in clearance of postprandial lipoproteins. Chunyu Zheng, Harvard School of Public Health
• Kinetics of apoB100 metabolism in miniature pigs following treatment with an inhibitior of 2,3- oxidosqualene cyclase: A novel cholesterol lowering agent. Murray Huff, University of Western Ontario

Washington 2005

• Berman/Zech Award Lecture -  Modeling of Human Apolipoprotein A-I and B Metabolism. Hugh Barrett, University of Western Australia
• Levy Award Lecture - Perspectives on VLDL and LDL ApoB-100 Metabolism-Insights that benefited Academia and Industry. David Bilheimer, Merck and Co. New Jersey
• Effects of CETP Inhibition on Apolipoprotein A-I Metabolism in Humans. Margaret Brousseau, Tufts University
• Using Mass Measurements in Fitting Apolipoprotein Tracer Data. Sekhar Ramakrishnan, Columbia University
• Effects of phytosterols on lipoprotein metabolism in subjects with the metabolic syndrome. Esther Ooi, University of Western Australia
• Commentary on Reverse Cholesterol Transport in Human Subjects from the perspective of Clinical Research and Kinetic Modeling. Charles Schwartz, Richmond, VA
• Naringenin mimics the kinetics of insulin-induced inhibition of apoB100- containing lipoprotein assembly in HepG2 cells through a mechanism independent of the insulin receptor. Emma Allister, University of Western Ontario
• Recycling of Apo(a), ApoA-I, and ApoA-IV on ApoB Containing Lipoproteins. Ernst Schaefer, Tufts University
• Delipidation models for apoB48 and B100 metabolism in the postprandial period. Chun-yu Zheng
• Transfer of dietary lipids into hepatocellular lipids and VLDL: An audience forum on FFA recycling. Elizabeth Parks, University of Minnesota
• A novel inhibitor of oxidosqualene:lanosterol cyclase enhances LDL apoB100 catabolism through decreased hepatic cholesterol synthesis and enhanced expression of intestinal ABCG5 and ABCG8. Murray Huff, University of Western Ontario
• Hepatic triglyceride synthesis and secretion in mice. John Millar, University of Pennsylvania
• A New Model of Golgi Protein Trafficking that hightlights the Role of Membrane Lipids. Robert Phair, Integrative Bioinformatics Inc.

Denver 2006

• Levy Award Lecture - HDL Metabolism. Katsunori Ikewaki, University of Jikei, Japan
• Berman/Zech Award Lecture - Modeling of Triglyceride Metabolism with Stable Isotope Tracers, Bruce Patterson, Washington University
• ApoB kinetics of lipoproteins containing apoE, apoCIII or both, Chunyu Zheng, Harvard University
• Models of apoCIII metabolism: Interpretation of tracer data and effect of atorvastatin on apoCIII metabolism in overweight, dyslipidemic men. Hugh Barrett, University of Western Australia
• Unexplained rapid clearance of modifed LDL tracers in cholesterol in primates: does it represent a novel pathway? Perry Colvin, Wake Forest University
• Atheroprotection with Infusion of ApoA-I Mimetic Peptide. Marcelo Amar, NIH
• One Reader's Difficulties in Understanding Modeling Results. Sekhar Ramakrishnan, Columbia University
• Using the kinetics of apoB100 metabolism to reveal the mechanism of action of ezetimibe plus simvastatin in miniature pigs. Murray Huff, University of Western Ontario
• Effects of Moderate and High Dose Atorvastatin on HDL Metabolism, Margaret Diffenderfer, Tufts University
• The Wonders of ApoB-48 ELISA. Elizabeth Teng Leary, Pacific Biometrics Inc.
• Effect of ezetimibe on the in vivo kinetics of apoB-48 and apoB-100 in men with primary hypercholesterolemia, Patrick Couture, Laval University
• Kinetic studies using stable isotopes. Yasuhisa Kurogi, Cambridge Isotopes
• Preliminary study of small dense LDL particle kinetics in humans. Benoît Lamarche, Laval University
• Effects of CETP inhibition on apoB-100 kinetics. John Millar, University of Pennsylvania
• Relationships between the Metabolism of TG rich Lipoproteins and HDL Particles. Ernst Schaefer, Tufts University

Chicago 2007

• Berman/Zech Award Lecture - ApoB kinetics in TRL and LDL. Chris Packard, University of Glasgow
• Levy Award Lecture - Effects of dietary factors on lipoprotein metabolism and atherosclerosis. Larry Rudell, Wake Forest University
• Effect of Postprandial Fat and Carbohydrate Intake on the Kinetics of ApoB with apoE and with apoC-III. Frank Sacks, Harvard University
• A mathematical model for CETP activity in vitro. Laura Potter, GlaxoSmithKline, Research Triangle Park
• The metabolism of HDL subspecies in inborn errors of HDL metabolism. Bela Asztalos, Lipid Metabolism Laboratory, Tufts University
• ApoB-48 metabolism in diabetes mellitus. Jean Charles Hogue, Laval University, Quebec
• The importance of using isotopic enrichment standards to calibrate GC/MS measurements. Bruce Patterson, Washington University
• Effects of CETP inhibition on human apolipoprotein metabolism. John Millar, University of Pennsylvania
• The effects of Atorvastatin on apoB-48 metabolism. Margaret Diffenderfer, Lipid Metabolism Laboratory, Tufts University
• In vivo metabolism of small dense LDL. Katsu Ikewaki, University of Jikei, Japan
• HDL subfraction metabolism in monkeys. Chunyu Zheng , Harvard School of Public Health
• Use of tracer-tracee Ratio (TTR) for enrichment Is largely a lipoprotein kinetic aberration. Sekhar Ramakrishnan, Columbia University
• Dose-dependent improvement in HDL metabolism with Rosuvastatin in the metabolic Syndrome. Hugh Barrett, University of Western Australia

Atlanta 2008

• Levy Award Lecture - Lipoprotein kinetics reveals the mechanism of action of lipid modifying drugs: Insights from cultured cells and animal models, Murray Huff, University of Western Ontario
• New approaches to modelling postprandial data – Population kinetics and the possibilities? Hugh Barrett, University of Western Australia
• ApoB Conversion Rate Constants Only As Good As the Pool Masses, Sekhar Ramakrishnan, Columbia University
• The effect of TRL ApoE content, size and concentration on LDL uptake - A systems biology approach, Brendan O'Malley, Unilever, Bedford, UK
• Non-CETP Mediated Transfer of HDL cholesteryl ester to LDL in mice, Marcelo Amar, National Institutes of Health
• Dose-dependent effect of rosuvastatin on very-low density lipoprotein apolipoprotein C-III kinetics in men with the metabolic syndrome, Esther Ooi, University of Western Australia
• Abnormal lipoproteins kinetics in ESRD HD patients, Katsu Ikewaki, Jikei University School of Medicine
• Diurnal rhythm, and other factors, that influence lipogenesis, Elizabeth Parks, University of Texas Southwestern Medical School
• Genetic Defects and Remodeling of HDL Particles, Ernst Schaefer, Lipid Metabolism Laboratory, Tufts University
• Inhibition of cholesterol absorption by ezetimibe increases the fractional clearance rate of postprandial triglyceride-rich lipoproteins in miniature pigs, Dawn Telford, University of Western Ontario
• Effects of ezetimibe and simvastatin, coadministered and alone, on the in vivo kinetics of apoB-48 in patients with primary hypercholesterolemia Andre Tremblay, Laval University, Quebec City
• Measurement of plasma free cholesterol flux: implications on cholesterol homeostasis, Marc Hellerstein, University of California, Berkeley
• HDL turnover based on the behavior of apoA-I only particles, Larry Rudel, Wake Forest University
• Modeling of oxylipin transport by lipoproteins,Greg Shearer, Sanford Research/University of South Dakota, Sioux Falls, SD
• The effects of interventions on plasma free cholesterol flux and reverse cholesterol transport in animal models, Jason Voogt, KineMed, Emmeryville, CA
• The Effects of Niacin on Human Apolipoprotein Metabolism, Margaret Diffenderfer, Lipid Metabolism Laboratory, Tufts University

Washington 2009

• Berman/Zech Award Lecture - Tracer data are of enrichments. Why then do we model activities? Sekhar Ramakrishnan, Columbia University
• Levy Award Lecture - Metabolic basis for hypertriglyceridemia and the dense LDL phenotype. Frank Sacks, Harvard University
• HDL particle metabolism and proteomics. Bela Asztalos, Lipid Metabolism Laboratory, Tufts University
• Modeling LDL interactions under flow in a bioreactor - a different playing field. Michael Fannon, University of Kentucky
• Effects of CETP inhibition and LXR agonists on HDL-Cholesteryl ester kinetics in a hamster model. Francois Briand, Physiogenex S.A.S
• Effect of a PPARdelta agonist on lipoprotein kinetics in the metabolic syndrome. Esther Ooi, School of Medicine and Pharmacology, University of Western Australia
• Update on assessment of reverse cholesterol transport. Jason Voogt, KineMed, San Francisco
• Effects of CETP inhibition on human apolipoprotein metabolism. Margaret Diffenderfer, Lipid Metabolism Laboratory, Tufts University
• Isolating the influence of apoCIII on metabolism of VLDL and LDL in vivo. Carlos Mendivil, Harvard University
• An overview of Lpa metabolism. Ernst Schaefer, Cardiovascular Research & Lipid Metabolism Laboratories, Tufts University
• The kinetics apoB100-containing lipoprotein trafficking in HepG2 cells: The impact of insulin and the citrus flavonoid naringenin. Murray Huff, University of Western Ontario
• Assessment of cholesterol synthesis and absorption in Familial Combined Hyperlipidemia. Thomas van Himbergen, Lipid Metabolism Laboratory, Tufts University